
This practical resource helps healthcare providers successfully implement and manage buprenorphine treatment programs for patients with opioid use disorder (OUD). The toolkit reviews buprenorphine pharmacology, evolving prescribing regulations, and best practices for medication-assisted treatment (MAT). It also highlights compliance assessment strategies—including prescription monitoring, medication counts, and drug testing—and provides guidance for developing effective monitoring protocols, mitigating diversion risk, selecting laboratory partners, and supporting long-term recovery outcomes. Designed for clinicians treating OUD and substance use disorder (SUD), the guide offers actionable insights to promote safe, evidence-based care and improve patient treatment success.