Phenazolam

What You Need to Know

Phenazolam Use Continues to Rise

  • Phenazolam, also known as clobromazolam, was first reported as detected in the United States in 2022.1
  • Though bromazolam has been the most commonly detected designer benzodiazepine identified through Aegis testing for the past year, phenazolam is now being detected more frequently than bromazolam in parts of the country.
  • For samples received in Q3 2025, Aegis identified phenazolam more often than other designer benzodiazepines in 5 states: Kentucky, New Jersey, Ohio, Oregon, and Tennessee.
  • Though published literature on phenazolam is limited, one study demonstrated that its potency may far exceed that of most benzodiazepines and designer benzodiazepines.2 This could create significant risk for adverse effects in individuals encountering this drug.
References
1. https://www.cfsre.org/images/monographs/Phenazolam-120622-CFSRE-Toxicology-Report.pdf
2. Manchester KR, Waters L, Haider S, Maskell PD. The blood-to-plasma ratio and predicted GABAA-binding affinity of designer benzodiazepines. Forensic Toxicol. 2022;40(2):349-356. doi:10.1007/s11419-022-00616-y

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