ortho-Methylfentanyl

What You Need to Know

About ortho-Methylfentanyl1

  • llicitly-manufactured fentanyl analog that is currently considered a
    Schedule I drug in the US
  • Effects from use can be similar to fentanyl
  • At time of publication, ortho-methylfentanyl has been detected in over
    700 samples originating from 24 unique states
  • Non-prescribed substances that are most commonly co-detected
    include: fentanyl, xylazine, cocaine, morphine, and fluoro fentanyl
Findings reflect reported results from samples received for testing between 12/9/2024-5/28/2025 and reported as of 5/29/2025.
States in Blue – ortho-Methylfentanyl detected
States in Grey – ortho-Methylfentanyl Not Tested or Not Detected
References
1. https://www.cfsre.org/nps-discovery/public-alerts/ortho-methylfentanyl-proliferating-across-northamerica-as-newest-synthetic-opioid-identified-in-fatal-drug-overdoses#:~:text=ortho%2DMethylfentanyl%20is%20an%20active,e.g.%2C%20para%2Dfluorofentanyl).

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