Novel Psychoactive Substance Testing

Novel Psychoactive Substance Testing

Aegis is pleased to offer industry-leading testing options to allow providers the opportunity to more completely understand an individual’s substance use pattern, and facilitate more informed care.

Novel psychoactive substances (NPS) are compounds designed to mimic the effects of prescription drugs, evade detection by typical drug testing methodologies, and avoid regulation. NPS can be described by numerous terms, including legal highs or research chemicals labelled ‘not for human use’.

  • NPS markets rapidly change in response to regulation from US and other international agencies.
  • NPS may potentiate drug interactions with prescription medications, leading to unintended overdoses.
  • Individuals are exposed to fentanyl, designer opioids and benzodiazepines knowingly, or unknowingly through counterfeit prescription drugs intended to mimic common drugs such as oxycodone, hydrocodone and alprazolam, among others.

Ordering Information
Aegis' NPS testing is available for urine or oral fluid specimens as an add-on by drug class. Providers may choose one or multiple classes based on medical necessity. 

Novel Psychoactive Substance Testing
The elements of our NPS test offerings are a testament to Aegis’ commitment to excellence and innovation. We continue to provide solutions that assist providers improve clinical care and prevent adverse outcomes. Current testing options include the following parent drugs and/or metabolites.

1-Napthyl U-47700   4Cl-Deschloroalprazolam   2-Fluoroamphetamine   4-CN-CUMYL-BUTINACA
2-Methyl AP-237   Adinazolam   2-Fluoromethamphetamine   4F-ABUTINACA
2-Napthyl U-47700   Bromazolam   2-Methoxymethamphetamine   4F-MDMB-BUTICA/4F-EMB-BUTICA
4-Trifluoromethyl U-47700   Clonazolam   3,4-DMMA   4F-MDMB-BUTINACA
Acryl Fentanyl   Desalkylgidazepam   3/4-Fluoroamphetamine   5F-AB-PFUPPYCA
AP-238   Deschloroetizolam   3/4-Fluoromethamphetamine   5F-AMB
Benzyl Fentanyl   Diclazepam   3/4-Methylmethcathinone   5F-BZO-POXIZID
Bromo Fentanyl   Etizolam   4F-3-methyl-alpha-PVP   5F-MDMB-PICA/5F-EMB-PICA
Brorphine   Flualprazolam   4-Fluoromethylphenidate   5F-MDMB-PINACA
Butonitazene   Flubromazepam   Alpha-D2PV   5F-PB-22
Chloro Fentanyl   Flubromazolam   Alpha-PHP   ADB-4en-PINACA
Cyclopropyl Fentanyl   Fluclotizolam   Alpha-PiHP   ADB-5Br-BUTINACA
Despropionyl Fluorofentanyl   Meclonazepam   Benzylone   ADB-5Br-INACA
Dipyanone   Metizolam   Butylone   ADB-5Br-PINACA
Flunitazene   Phenazepam   Chloro-N,N-DMC   ADB-BINACA
Fluoro Fentanyl     Dimethylone   ADB-BUTINACA
Fluoroisobutyryl Fentanyl   HALLUCINOGENS/DISSOCIATIVES   Eutylone   ADB-FUBIATA
Isotonitazene   25E-NBOH   MBZP   ADB-FUBICA
Methyl-THF-Fentanyl   2F-2-oxo-PCE   MDPHP   ADB-HEXINACA
Metonitazene   2F-Deschloroketamine   Methylenedioxy-PV8   ADB-PHETINACA
Norcarfentanil   3Cl-PCP   N,N-dimethyl Pentylone   ADB-PINACA
N-piperidinyl Etonitazene   3F-PCP   N-butyl Hexedrone   BZO-CHMOXIZID
N-pyrrolidino Etonitazene   3-OH-PCE   N-cyclohexyl Butylone   BZO-HEXOXIZID
N-pyrrolidino Metonitazene   3-OH-PCP   N-ethyl Heptedrone   BZO-POXIZID
N-pyrrolidino Protonitazene   Deschloroketamine   N-ethyl Hexedrone   CH-FUBIATA
Protonitazene   Deschloro-N-Ethylketamine   N-ethyl Pentedrone   CH-PIATA
Valeryl Fentanyl   Fluorexetamine   NM N-cyclohexyl Methylone   FUB-PB-22
    Hydroxetamine   N-propyl Butylone   JWH-018
OTHER   Methoxy PCE   Pentylone   JWH-073
Medetomidine   Methoxy PCP   TFMPP    MDMB-4en-PINACA
Phenibut       MDMB-5Br-INACA
Tianeptine       MMB-4en-PICA
Xylazine       MMB-4en-PINACA

A complete and up to date list of the analytes contained in each listed drug class can be found at:

*Parent drug listed for informational purposes only and not included in testing. Analytes listed for each drug class are current as of September 11, 2023. Updates and enhancements to the drug classes are made from time to time.

Recorded Webinars Available:

If you are a Healthcare Provider seeking information please contact your Regional Sales Manager or Client Services team at 1.800.533.7052 or email